Variable | Oral Study | Intravenous Study | ||||
---|---|---|---|---|---|---|
TR- Rats (n = 8) | Wild-Type Rats (n = 8) | TR- Rats (n = 4) | Wild-Type Rats (n = 4) | |||
Cmax (ng/ml) | 240 ± 93.2*** | 19.2 ± 8.03 | ||||
Tmax (h) | 0.5 (0.5-0.5) | 0.5 (0.5-0.5) | ||||
AUC (ng · h/ml) | 387.0 ± 97.7*** | 63.0 ± 34.3 | 609.3 ± 137.6** | 128.6 ± 13.1 | ||
CL (l/kg/h) | 8.50 ± 1.72*** | 39.2 ± 4.33 | ||||
V (l/kg) | 3.29 ± 0.72** | 14.1 ± 2.62 | ||||
t1/2 (min) | 16.1 ± 0.97 | 14.9 ± 1.5 | ||||
Ae (μg) | 166 ± 89.5* | 1.87 ± 1.58 | ||||
CLR (l/kg/h) |
|
| 0.695 ± 0.325* | 0.042 ± 0.034 |