Test Compound | n | f2 |
---|---|---|
Verapamil | 3 | 0.6 ± 0.2 μM (0.3 ± 0.1 μg/ml)a |
Quinidine | 4 | 2.4 ± 0.9 μM (0.8 ± 0.3 μg/ml)a |
Kava-kava | 3 | 0.17 ± 0.02 mg/ml |
Desmethoxyyangonin | 3 | 17.1 ± 0.6 μM (4.4 ± 0.2 μg/ml) |
Methysticin | 3 | 47.5 ± 17.1 μM (13.0 ± 4.7 μg/ml)** |
Dihydromethysticin | 3 | 54.6 ± 10.1 μM (15.0 ± 2.8 μg/ml)** |
Kavain | 4 | 88.1 ± 25.2 μM (20.3 ± 5.8 μg/ml)** |
Dihydrokavain | 3 | 88.6 ± 13.9 μM (20.6 ± 3.2 μg/ml)** |
Yangonin | 4 | N.D.† |
f2, concentration needed to double baseline fluorescence; N.D., not definable; n, number of experiments, each performed in octuplet.
↵ a The f2 values for verapamil and quinidine have already been determined and published previously (Fröhlich et al., 2004).
↵** p < 0.01.
↵† Correct calculation of the f2 value for yangonin was not possible due to the very limited solubility.