Percent (%) inhibition of human liver microsomal metabolism of bortezomib using monoclonal antibodies (mAbs) and chemical inhibitors
P450 Isoform | % Inhibition of Bortezomib Metabolisma | ||
|---|---|---|---|
| Inhibitory mAbs | Chemical Inhibition | ||
| 1A2 | 18.0 | 15.8 | |
| 2C9 | 5.4 | 13.6 | |
| 2C19 | 23.0 | 33.5 | |
| 2D6 | 6.6 | 23.4 | |
| 3A4 | 79.0 | 69.8 | |
↵ a Relative contribution of P450.