TABLE 5

B/P, CSF/plasma, and CSF/brain AUC ratios in FVB and mdr1a/1b (-/-, -/-) mice for non-CNS drugs


Compound

Brain/Plasma

CSF/Plasma

CSF/Brain
FVB
KO
KO/WT
FVB
KO
KO/WT
FVB
KO
KO/WT
Amiodarone 0.080 1.7 21* N.D. N.D. N.D. N.D.
Loperamide 0.55 5.1 9.3* 0.0019 0.012 6.3* 0.0034 0.0023 0.68
Loratadine 0.54 1.0 1.9 N.D. N.D. N.D. N.D.
Prazosin 0.22 0.44 2.0 0.034 0.063 2.0 0.16 0.14 0.90
Prednisone 0.12 0.28 2.3 3.1 2.4 0.77 25 8.6 0.34
Quinidine 0.28 10 36* 0.0067 0.068 10.1* 0.024 0.0067 0.28
Ritonavir 0.015 0.018 1.2 N.D. N.D. N.D. N.D.
Verapamil
0.34
5.6
17*
0.0018
0.016
8.7*
0.0052
0.0028
0.53
  • N.D., not detected.

  • * p < 0.05, probability of KO/WT ratio >2.