FVB | mdr 1a/1b (-/-, -/-) | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Drug | Plasma | AUC | Plasma | AUC | ||||||||||||||
Cmax | Tmax | Plasma | Brain | CSF | Cmax | Tmax | Plasma | Brain | CSF | |||||||||
ng/ml | h | ng · h/ml | ng/ml | h | ng · h/ml | |||||||||||||
Amiodarone | 39.5 ± 5.3 | 2.5 | 153 ± 14 | 12.8 ± 1.8 | N.D. | 38.3 ± 2.9 | 2.5 | 141 ± 9 | 241 ± 23 | N.D. | ||||||||
Loperamide | 96.0 ± 5.3 | 0.5 | 107 ± 7 | 59.3 ± 8.7 | 0.20 ± 0.03 | 172 ± 16 | 0.5 | 194 ± 12* | 994 ± 43 | 2.3 ± 0.5 | ||||||||
Loratadine | 170 ± 24 | 0.5 | 244 ± 16 | 131 ± 10 | N.D. | 144 ± 5 | 0.5 | 263 ± 12 | 255 ± 13 | N.D. | ||||||||
Prazosin | 215 ± 15 | 0.5 | 221 ± 12 | 47.7 ± 2 | 7.6 ± 1.6 | 198 ± 15 | 0.5 | 230 ± 13 | 100 ± 4 | 14.4 ± 2.8 | ||||||||
Prednisone | 58.1 ± 4.8 | 0.5 | 48.8 ± 4.9 | 6.02 ± 1.64 | 152 ± 10 | 72.8 ± 3.8 | 0.5 | 62.6 ± 7.4 | 17.6 ± 2.2 | 151 ± 17 | ||||||||
Quinidine | 1760 ± 427 | 0.5 | 1480 ± 242 | 409 ± 37 | 10.0 ± 0.9 | 1110 ± 122 | 0.5 | 1350 ± 105 | 13,600 ± 782 | 92.0 ± 7.3 | ||||||||
Ritonavir | 223 ± 47 | 0.5 | 573 ± 54 | 8.7 ± 0.5 | N.D. | 331 ± 76 | 0.5 | 551 ± 77 | 10.0 ± 0.7 | N.D. | ||||||||
Verapamil | 358 ± 29 | 0.5 | 323 ± 23 | 110 ± 10 | 0.6 ± 0.1 | 330 ± 7 | 0.5 | 410 ± 17* | 2310 ± 100 | 6.40 ± 1.14 |
N.D., not detected.
↵* p < 0.05 vs. corresponding FVB AUC.