TABLE 3

AUC, Cmax, and Tmax values for non-CNS drugs in FVB and mdr1a/1b (-/-, -/-) mice after subcutaneous administration



FVB

mdr 1a/1b (-/-, -/-)
Drug Plasma
AUC
Plasma
AUC

Cmax
Tmax
Plasma
Brain
CSF
Cmax
Tmax
Plasma
Brain
CSF
ng/ml h ng · h/ml ng/ml h ng · h/ml
Amiodarone 39.5 ± 5.3 2.5 153 ± 14 12.8 ± 1.8 N.D. 38.3 ± 2.9 2.5 141 ± 9 241 ± 23 N.D.
Loperamide 96.0 ± 5.3 0.5 107 ± 7 59.3 ± 8.7 0.20 ± 0.03 172 ± 16 0.5 194 ± 12* 994 ± 43 2.3 ± 0.5
Loratadine 170 ± 24 0.5 244 ± 16 131 ± 10 N.D. 144 ± 5 0.5 263 ± 12 255 ± 13 N.D.
Prazosin 215 ± 15 0.5 221 ± 12 47.7 ± 2 7.6 ± 1.6 198 ± 15 0.5 230 ± 13 100 ± 4 14.4 ± 2.8
Prednisone 58.1 ± 4.8 0.5 48.8 ± 4.9 6.02 ± 1.64 152 ± 10 72.8 ± 3.8 0.5 62.6 ± 7.4 17.6 ± 2.2 151 ± 17
Quinidine 1760 ± 427 0.5 1480 ± 242 409 ± 37 10.0 ± 0.9 1110 ± 122 0.5 1350 ± 105 13,600 ± 782 92.0 ± 7.3
Ritonavir 223 ± 47 0.5 573 ± 54 8.7 ± 0.5 N.D. 331 ± 76 0.5 551 ± 77 10.0 ± 0.7 N.D.
Verapamil
358 ± 29
0.5
323 ± 23
110 ± 10
0.6 ± 0.1
330 ± 7
0.5
410 ± 17*
2310 ± 100
6.40 ± 1.14
  • N.D., not detected.

  • * p < 0.05 vs. corresponding FVB AUC.