Kinetic parameters for metabolism of enalarpil by S9 enzymes derived from homogeneous hepatocytes, and the transport constants derived from initial uptake velocities by homogeneous isolated rat hepatocytes (data of Abu-Zahra et al., 2000 ; Abu-Zahra and Pang, 2000 )
Km | Vmax | CLint = Vmax/Km | |
|---|---|---|---|
| μM | ml/min/g | ||
| Homogeneous hepatocytes (S9 metabolism) | 1308 ± 419 | 8 ± 3 nmol/min/mg S9 protein or 800 nmol/min/g livera | 0.61 |
| Homogeneous hepatocytes (transport) | 344 to 361 | 11.0 to 11.6 nmol/min/106 cells or 1,425 nmol/min/g liverb | 4.00 |
| Transport/metabolism |
|
|
6.56
|
↵ a Based on 100 mg of protein per g of liver.
↵ b Based on 130 × 106 cells per g of liver (Zahlten and Stratman, 1974).