Parameter values used for simulation of decay profiles of a hypothetic drug with the physiologically based liver model shown in Fig. 3
Description | Symbol | Assigned Values |
|---|---|---|
| Doses (μmol/200 ml) | Dose | 10 and 100 |
| Compartment volumes (ml/g) | ||
| Reservoir plasma | V R | 20 |
| Hepatic plasma | V PL | 0.128 |
| Hepatic tissue water | V L | 0.6 |
| Canalicular bile | V bile | 0.004 |
| Flow rates (ml/min/g) | ||
| Hepatic plasma | Q L | 0.8 |
| Bile | Q bile | 0.001 |
| Clearances for hypothetical drug (ml/min/g) | ||
| Biliary intrinsic clearance | CLint, sec | 0.1 (to 0.5, 0.25, and 0.05) |
| Basolateral influx clearance | CLinflux | 4 (to 8, 1, and 0.5) |
| Basolateral efflux clearance | CLefflux | 2 (to 4, 1, and 0.5) |
| Nonlinear metabolism - Michaelis-Menten parameters | ||
| Maximum velocity (nmol/min/g) | V max | 5 |
| Michaelis-Menten constant (μM) | K m | 20 |
| Fractions unbound for drug | ||
| Plasma | f P | 0.55 |
| Tissue |
f
L
| 0.55 |