Parameter values used for simulation of decay profiles of a hypothetic drug with the physiologically based liver model shown in Fig. 3



Assigned Values
Doses (μmol/200 ml) Dose 10 and 100
Compartment volumes (ml/g)
Reservoir plasma V R 20
Hepatic plasma V PL 0.128
Hepatic tissue water V L 0.6
Canalicular bile V bile 0.004
Flow rates (ml/min/g)
Hepatic plasma Q L 0.8
Bile Q bile 0.001
Clearances for hypothetical drug (ml/min/g)
Biliary intrinsic clearance CLint, sec 0.1 (to 0.5, 0.25, and 0.05)
Basolateral influx clearance CLinflux 4 (to 8, 1, and 0.5)
Basolateral efflux clearance CLefflux 2 (to 4, 1, and 0.5)
Nonlinear metabolism - Michaelis-Menten parameters
Maximum velocity (nmol/min/g) V max 5
Michaelis-Menten constant (μM) K m 20
Fractions unbound for drug
Plasma f P 0.55
f L