Description | Symbol | Assigned Values |
---|---|---|
Doses (μmol/200 ml) | Dose | 10 and 100 |
Compartment volumes (ml/g) | ||
Reservoir plasma | V R | 20 |
Hepatic plasma | V PL | 0.128 |
Hepatic tissue water | V L | 0.6 |
Canalicular bile | V bile | 0.004 |
Flow rates (ml/min/g) | ||
Hepatic plasma | Q L | 0.8 |
Bile | Q bile | 0.001 |
Clearances for hypothetical drug (ml/min/g) | ||
Biliary intrinsic clearance | CLint, sec | 0.1 (to 0.5, 0.25, and 0.05) |
Basolateral influx clearance | CLinflux | 4 (to 8, 1, and 0.5) |
Basolateral efflux clearance | CLefflux | 2 (to 4, 1, and 0.5) |
Nonlinear metabolism - Michaelis-Menten parameters | ||
Maximum velocity (nmol/min/g) | V max | 5 |
Michaelis-Menten constant (μM) | K m | 20 |
Fractions unbound for drug | ||
Plasma | f P | 0.55 |
Tissue |
f
L
| 0.55 |