TABLE 7

Simulations based on assigned parameters shown in Table 6 (cumulative metabolite formation and excretion were estimated to asymptotic values, then normalized to the dose)


Conditions

ml/min/g

Area Under the Curve

Total Metabolite Formation (fraction of dose)

Cumulative Excretion (fraction of dose)
Low Dose
High Dose
Low Dose
High Dose
Low Dose
High Dose
μM · min
Set I: Changing CLint,sec 0.5 3.11 34.0 0.245 0.087 0.755 0.913
0.25 4.02 48.9 0.371 0.132 0.629 0.868
0.1 5.61 87.1 0.573 0.232 0.427 0.768
0.05 6.84 136. 0.719 0.345 0.281 0.655
Set II: Changing CLinflux 8 3.75 53.0 0.510 0.168 0.490 0.832
4 5.61 87.1 0.573 0.232 0.427 0.768
1 15.3 245. 0.664 0.418 0.336 0.582
0.5 27.7 418. 0.687 0.516 0.313 0.484
Set III: Changing CLefflux 4 8.59 142. 0.622 0.314 0.378 0.686
2 5.61 87.1 0.573 0.232 0.427 0.768
1 3.93 55.0 0.517 0.172 0.483 0.828

0.5
2.96
37.2
0.466
0.133
0.534
0.867