Conditions | ml/min/g | Area Under the Curve | Total Metabolite Formation (fraction of dose) | Cumulative Excretion (fraction of dose) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Low Dose | High Dose | Low Dose | High Dose | Low Dose | High Dose | |||||
μM · min | ||||||||||
Set I: Changing CLint,sec | 0.5 | 3.11 | 34.0 | 0.245 | 0.087 | 0.755 | 0.913 | |||
0.25 | 4.02 | 48.9 | 0.371 | 0.132 | 0.629 | 0.868 | ||||
0.1 | 5.61 | 87.1 | 0.573 | 0.232 | 0.427 | 0.768 | ||||
0.05 | 6.84 | 136. | 0.719 | 0.345 | 0.281 | 0.655 | ||||
Set II: Changing CLinflux | 8 | 3.75 | 53.0 | 0.510 | 0.168 | 0.490 | 0.832 | |||
4 | 5.61 | 87.1 | 0.573 | 0.232 | 0.427 | 0.768 | ||||
1 | 15.3 | 245. | 0.664 | 0.418 | 0.336 | 0.582 | ||||
0.5 | 27.7 | 418. | 0.687 | 0.516 | 0.313 | 0.484 | ||||
Set III: Changing CLefflux | 4 | 8.59 | 142. | 0.622 | 0.314 | 0.378 | 0.686 | |||
2 | 5.61 | 87.1 | 0.573 | 0.232 | 0.427 | 0.768 | ||||
1 | 3.93 | 55.0 | 0.517 | 0.172 | 0.483 | 0.828 | ||||
| 0.5 | 2.96 | 37.2 | 0.466 | 0.133 | 0.534 | 0.867 |