TABLE 1

Effect of TCDD on cytotoxicity of TMS in human tumor cells

MCF-7 and HL-60 cells were treated with 2 nM TCDD in the presence or absence of TMS (1 μM) for 72 h. MTT assays were performed to measure cell proliferation. The level in control cells at 0 h was set at 100%. Results represent the means ± S.D. of five different experiments.

Treatment
MCF-7 Proliferation
HL-60 Proliferation
-TCDD
+TCDD
-TCDD
+TCDD
% of control % of control
DMSO 914 ± 164 526 ± 79* 655 ± 54 296 ± 26*
TMS
313 ± 66*
49 ± 13*,#
178 ± 21*
52 ± 10*,#

  • ↵* Significantly different from DMSO-treated groups (p < 0.05).

  • ↵# Significantly different from TMS-treated groups (p < 0.05).