TABLE 1

Recovery of radioactivity in bile, urine, and feces following oral and intravenous administration of [¹⁴C]MRL-C to male rats, dogs, and monkeys

Species	Dose	Percentage of Radioactive Dose^a
Species	Dose			Bile	Urine	Feces	Total^b
Rat	2 mg/kg p.o. n = 2	96	0.2	N.D.	96
	1 mg/kg i.v. n = 3	97 ± 10	0.8 ± 0.5	N.D.	98 ± 10
Dog	2 mg/kg p.o. n = 3	87 ± 2	2.0 ± 0.2	5.7 ± 2.4	93 ± 4
	0.5 mg/kg i.v. n = 3	89 ± 5	2.6 ± 1.6	3.0 ± 3.4	95 ± 3
Monkey	2 mg/kg p.o. n = 2	27	42	12	88
	0.5 mg/kg i.v. n = 2	64	24	4.7	94

N.D., not determined.
↵ a [¹⁴C]MRL-C was administered to adult, male bile duct-cannulated animals at the doses indicated. Collection periods were 0 to 72 h (rats) and 0 to 120 h (dogs and monkeys). Dosing vehicles and the volume administered may be found under the Materials and Methods. Mean ± standard deviation (n = 3) or average (n = 2) values are listed.
↵ b Total values include cage washes and cage wipes.