Compound | Cofactor | Percentage Metabolism | ||||||
---|---|---|---|---|---|---|---|---|
Rat | Dog | Monkey | Human | |||||
MRL-C | NADPH | 20 | 60 | 80 | 43 | |||
MRL-C | UDPGA | 74 | 67 | 84 | 76 | |||
MRL-Ca | NADPH and UDPGA | 78 | 83 | 94 | 88 | |||
Acyl glucuronide | NADPH | 6 | 34 | 73 | 17 |
↵ a The acyl glucuronide represented ∼85, 70, 35, and 65% of total metabolism in incubations with rat, dog, monkey, and human liver microsomes, respectively.