Concentration | Uptake at pH 7.4 | Uptake at pH 6.0 | |||||
---|---|---|---|---|---|---|---|
Uninjected | MCT6-Expressing | Uninjected | MCT6-Expressing | ||||
μM | μl/oocyte | μl/oocyte | |||||
[3H]Bumetanide | 0.1 | 0.04 ± 0.02 | 0.77 ± 0.02* | 0.11 ± 0.01* | 0.83 ± 0.09* | ||
[3H]Estrone-3-sulfate | 0.01 | 0.07 ± 0.03 | 0.08 ± 0.001 | 0.13 ± 0.01 | 0.17 ± 0.02 | ||
[14C]p-Aminohippuric acid | 5 | 0.10 ± 0.03 | 0.10 ± 0.006 | 0.09 ± 0.01 | 0.12 ± 0.01 | ||
[3H]Probenecid | 0.5 | 0.53 ± 0.01 | 0.76 ± 0.06* | 2.44 ± 0.22* | 1.88 ± 0.12* | ||
[3H]Prostaglandin F2α | 0.001 | 0.26 ± 0.04 | 0.39 ± 0.02* | 0.69 ± 0.05* | 1.21 ± 0.07* | ||
[3H]Valproic acid | 0.01 | 0.62 ± 0.10 | 0.58 ± 0.93 | 6.53 ± 0.17 | 6.43 ± 0.18 | ||
[14C]Salicylic acid | 5 | 0.34 ± 0.03 | 0.32 ± 0.01 | 2.34 ± 0.25 | 2.47 ± 0.19 | ||
[3H]Hexanoic acid | 0.03 | 2.20 ± 0.17 | 2.25 ± 0.11 | 5.77 ± 0.69 | 4.97 ± 0.27 | ||
[14C]l-Leucine | 4 | 1.67 ± 0.27 | 2.08 ± 0.10 | 3.60 ± 0.55 | 3.67 ± 0.16 | ||
[14C]Nateglinide | 57 | 0.20 ± 0.01 | 0.41 ± 0.05* | 2.12 ± 0.08 | 2.54 ± 0.05* | ||
[14C]Nateglinide | 8 | 0.20 ± 0.04 | 0.90 ± 0.07*,a | N.D. | N.D. |
N.D., not determined.
↵ a Uptake was measured for 60 min.