Pharmacokinetic Parametera (Unit) | Phenotyping Metric for | Mean (% CV) in Test Period | Mean (% CV) in Reference Period |
---|---|---|---|
UR6-12 h (OH-tolbut. + carboxytolbut.)/tolbut. | CYP2C9 | 525 (42.6) | 664 (33.9) |
AUC0-∞ tolbutamide (μg/ml · h) | 160.9 (16.3) | 154.6 (15.1) | |
CL/F tolbutamide (ml/min) | CYP2C9 | 12.93 (16.3) | 13.44 (15.1) |
Cmax tolbutamide (μg/ml) | 11.7 (11.1) | 12.3 (12.3) | |
tmax tolbutamide (h) | 3.99 (4.5) | 3.80 (5.0) | |
t1/2, λz tolbutamide (h) | 8.27 (12.9) | 7.70 (14.0) | |
Tolbutamide plasma concentration 24 h postdose (μg/ml) | CYP2C9 | 2.00 (27.4) | 1.82 (30.9) |
Ae0-8 h 4′-OH-mephenytoin (% of dose) | CYP2C19 | 18.2 (195) | 19.3 (228) |
Paraxanthine/caffeine plasma ratio 6 h postdose | CYP1A2 | 0.49 (37) | 0.51 (39) |