Estimations of percentage contribution of human cytochrome P450 enzymes to sertraline N-deamination
Microsomes | CYP1A2 | CYP2C19 | CYP3A |
|---|---|---|---|
| From inhibition data Pooled (HL-MIX-101) | <1 | 15 | 85 |
| From rP450s using the relative activity factor approach | 2.2 | 35 | 63 |