Activity | System | Microsomal Protein Concentration | Ki (Mean ± S.E.) |
---|---|---|---|
mg/ml | μM | ||
Amodiaquine N-deethylase | Pooled human liver microsomes | 0.025 | 0.014 ± 0.001 |
HG42 (high CYP2C8 activitya) | 0.025 | 0.018 ± 0.001 | |
HG43 (low CYP2C8 activityb) | 0.025 | 0.038 ± 0.004 | |
rhCYP2C8 | 0.005 | 0.0092 ± 0.0009 | |
Rosiglitazone N-demethylase | Pooled human liver microsomes | 0.05 | 0.11 ± 0.02 |
rhCYP2C8 | 0.025 | 0.019 ± 0.002 | |
Paclitaxel 6α-hydroxylase | Pooled human liver microsomes | 0.25 | 0.15 ± 0.02 |