TABLE 2

Dialysis kinetic data and physicochemical data

Compound
Charge Type
105Pe/cm s-1
Log D7.4
pKa
log P
2-Ethoxybenzamidea Neutral 19 1.34 1.34
Albendazolea Neutral 2.5 3.29 3.29
Astemizole Base 1.8 4.14 8.35b 5.14c
Betaxolola Base 7.4 0.42 9.38 2.40
Bumetanidea Acid 7.9 0.31 4.5 3.21
Cerivastatina Acid 8.9 1.44 4.3 4.54
Clozapinea Base 24.8 2.9 8.0 3.60
Diazepama Neutral 15.9 2.25 2.25
Glyburidea Acid 5.1 2.19 5.3 4.29
Indapamidea Neutral 11.4 1.76 1.76
Isradipinea Neutral 14.1 3.75 3.75
Metoprolol Base 8.3 -0.21 9.6d 1.99c
Metyraponea Neutral 9.6 1.37 1.37
Omeprazole Neutral 14.2 2.08 2.08
Oxaprozina Acid 10 1.61 4.2 4.81
Propranolola Base 21.6 1.05 9.45 3.10
Verapamila
Base
6.7
2.57
8.92
4.10

  • ↵ a Log D7.4, log P, and pKa data from Austin et al. (2002).

  • ↵ b Data from Dollery (1999).

  • ↵ c Calculated using log P = logD7.4 + log(1 + 10pKa-7.4) (Taylor, 1990). Log P = log D7.4 for compounds designated as being neutral.

  • ↵ d Data from Medchem Database (Daylight Chemical Information Systems, Inc., Mission Viejo, CA).