TABLE 2

Relative duodenal CYP3A4 and P-gp expression values (arbitrary units) in men and women with corresponding age ranges

All Subjects
White Subjects
CYP3A5 Nonexpressors
<45 Years of Age
Men
Women
Men
Women
Men
Women
Men
Womena
Age (yr)
    Mean 28 41 28 44 27 43 27 27
    Range 19-49 18-64 19-48 18-64 19-48 19-64 19-42 18-42
CYP3A4 n = 45 n = 45 n = 37 n = 37 n = 31 n = 37 n = 42 n = 21
    Mean 0.93 0.93 0.89 0.89 0.93 0.91 0.91 1.05
    95% CI for difference of means [-0.14, 0.14] [-0.16, 0.16] [-0.16, 0.19] [-0.33, 0.06]
    p Valueb 0.98 0.97 0.84 0.14
    Median 0.95 0.89 0.94 0.89 0.93 0.90 0.95 1.01
    95% CI for difference of medians [-0.30, 0.26] [-0.33, 0.24] [-0.42, 0.33] [-0.22, 0.55]
p Valuec 0.89 0.88 0.79 0.18
P-gp n = 46 n = 45 n = 37 n = 37 n = 31 n = 34 n = 43 n = 21
    Mean 0.66 0.73 0.64 0.77 0.67 0.71 0.64 0.77
    Mean (log10 scale) -0.22 -0.18 -0.21 -0.18 -0.20 -0.19 -0.22 -0.16
    95% CI for difference of means (log10 scale) [-0.10, 0.5] [-0.12, 0.04] [-0.10, 0.08] [-0.15, 0.03]
    p Valueb 0.55 0.34 0.23 0.80
    Median 0.69 0.65 0.68 0.68 0.72 0.63 0.68 0.65
    95% CI for difference of medians [-0.19, 0.18] [-0.18, 0.18] [-0.26, 0.16] [-0.20, 0.32]
    p Valuec
0.91
0.58
0.40
0.50

  • CI, confidence interval.

  • ↵ a All premenopausal women were younger than 45 years of age.

  • ↵ b Comparison of men to women (log10 scale) by the Student's t test.

  • ↵ c Comparison of men to women by the Wilcoxon-Mann-Whitney U test.