The IC50 values of procainamide, corticosterone, and amantadine for [14C]pramipexole uptake Data shown in Figs. 5 and 6 were used to determine the IC50 values of procainamide, corticosterone, and amantadine for the uptake of pramipexole by rOCT1- and rOCT2-injected oocytes and rat kidney slices.
Inhibitor | Pramipexole Uptake (IC50) | ||||
|---|---|---|---|---|---|
| rOCT1 | rOCT2 | Kidney Slice | |||
| μM | |||||
| Procainamide | 7.7 ± 0.62 | 167.0 ± 124 | 47.0 ± 33.3 | ||
| Corticosterone | 163.7 ± 35.1 | 10.7 ± 3.61 | 47.7 ± 33.6 | ||
| Amantadine | 76.3 ± 14.4 | 270.9 ± 160 | 149.4 ± 75.5 | ||