Compound | MDR1-MDCK Efflux Ratio (2 μM) | MDCK B-A/A-B (2 μM) | Km in ATPase Assay |
---|---|---|---|
μM | |||
Pravastatin acid | 1.87 | 1.51 | N.A. |
Atorvastatin acid | 4.46 | 2.26 | N.A. |
Atorvastatin lactone | 2.32 | 4.31 | 3.61 |
Lovastatin acid | 3.17 | 1.58 | N.A. |
Lovastatin lactone | 2.17 | 1.16 | 11.5 |
Simvastatin acid | 2.00 | 1.31 | N.A. |
Simvastatin lactone | 0.93 | 0.46 | 12.3 |
Prazosina | 3.50 | 1.80 | not applicable |
Quinidinea | 15.0 | 4.1 | not applicable |
Verapamilb | not applicable | not applicable | 7.55 |