TABLE 2

Excretion of radioactivity (as percentage of administered dose) in mouse, rat, dog, and human following single oral doses of [14C]-UK-427,857

Species
Dose
Urine Excretion
Feces Excretion
Total Excretion
Total Excretiona
mg/kg 0-t b 0-t c 0-24 h 0-t c
Mouse (n = 3) 200 10.0 86.9 94.0 97.5
Male rat (n = 2) 100 4.5 93.7 93.2 98.3
Female rat (n = 2) 100 7.5 88.4 93.5 95.9
Male dog (n = 1) 5 6.8 86.0 4.4 93.2
Female dog (n = 1) 5 16.5 72.0 47.3 89.3
Human (n = 3)
3.2
19.6
76.4
19.6
96.0

  • ↵ a Includes cage washes in the case of animal species

  • ↵ b t = 96 h, mouse, rat, and dog; 168 h, human

  • ↵ c t = 96 h, mouse and rat; 168 h, dog and human