Effect of protein concentration on the hepatic uptake of [3H]caspofungin in the perfused rat liver
Radioactivity in the liver values are the mean ± S.D. (n = 3). The total concentration of [3H]caspofungin added to the perfusate was 10 μg/ml.
Protein Concentration in Perfusate (%) | Unbound Fraction in Perfusatea | Initial Free Drug Concentration in Perfusate | Radioactivity in Liver at End of Perfusion |
|---|---|---|---|
| % | μg/ml | % of dose | |
| 0.1 | 26.7 | 2.67 | 43.3 ± 4.5 |
| 0.5 | 8.3 | 0.83 | 18.9 ± 2.0 |
| 4.0 | 2.9 | 0.29 | 4.9 ± 0.5 |
↵ a Unbound fraction in perfusate values are an average of two determinations.