BCRP-mediated efflux of E3S in Caco-2 cells on days 5, 12, and 19 after seeding
Data are expressed as mean ± S.E.M. (n = 3)
Papp × 106 | |||||
|---|---|---|---|---|---|
| A-to-B | B-to-A | Ratio (B/A) | |||
| cm/s | |||||
| 5 days after cell seeding | |||||
| [3H]E3S | 5.7 ± 0.3 | 46.1 ± 1.0 | 8.1 | ||
| [3H]E3S + Ko143 (1 μM) | 9.2 ± 1.4 | 8.0 ± 0.3 | 0.9 | ||
| 12 days after cell seeding | |||||
| [3H]E3S | 4.1 ± 0.3 | 63.0 ± 1.4 | 15.6 | ||
| [3H]E3S + Ko143 (1 μM) | 11.2 ± 0.7 | 11.0 ± 0.9 | 1.0 | ||
| 19 days after cell seeding | |||||
| [3H]E3S | 4.5 ± 0.1 | 58.0 ± 0.2 | 12.8 | ||
| [3H]E3S + Ko143 (1 μM) | 8.7 ± 0.9 | 6.0 ± 0.4 | 0.7 | ||