Correlation coefficients between UGT-selective catalytic activities and fluoroquinolone glucuronidation activities by human liver microsomes from 14 individual donors
UGT-Specific Reaction | Correlation Coefficient (r) | ||||||
|---|---|---|---|---|---|---|---|
| LVFX | GPFX | MFLX | STFX | ||||
| β-Estradiol 3-glucuronidation | 0.823 | 0.594 | 0.706 | 0.756 | |||
| (P = 0.0003) | (P = 0.025) | (P = 0.005) | (P = 0.002) | ||||
| Trifluoperazinc glucuronidation | 0.417 | 0.323 | 0.502 | 0.347 | |||
| (P = 0.138) | (P = 0.260) | (P = 0.067) | (P = 0.224) | ||||
| Propofol glucuronidation | 0.661 | 0.787 | 0.408 | 0.564 | |||
|
| (P = 0.010) | (P = 0.0008) | (P = 0.147) | (P = 0.036) | |||