TABLE 4

Activity of recombinant human UGTs toward HFC and trifluoperazine


Enzyme Preparation

Glucuronidation Velocity
HFC
Trifluoperazine
nmol/min/mg
UGT1A1 1.4 ± 0.1 N.D.
UGT1A3 1.7 ± 0.3 N.D.
UGT1A4 N.D. 0.7 ± 0.3
UGT1A6 8 ± 2 N.D.
UGT1A7 1.6 ± 0.5 N.D.
UGT1A8 1.8 ± 0.1 N.D.
UGT1A9 4.2 ± 0.2 N.D.
UGT1A10 1.8 ± 0.1 N.D.
UGT2B4 4.2 ± 0.2 N.D.
UGT2B7 0.6 ± 0.1 N.D.
UGT2B15 4.3 ± 0.3 N.D.
HLM
2.9 ± 0.9
N.D.
  • N.D., not detected (<0.3 nmol/min/mg).