Time course of doxorubicin metabolite tissue levels in control versus LPS-treated mice following administration of doxorubicin at a 5 mg/kg i.v. dose Values represent mean ± S.E.M. (n = 5) of absolute amounts in ng DOX equivalents per g of tissue.
1 h | 8 h | |||||
|---|---|---|---|---|---|---|
| Control | LPS | Control | LPS | |||
| Liver | ||||||
| M2 | 1170 ± 872 | 1170 ± 183 | 307 ± 58 | 332 ± 50 | ||
| M3 | 1096 ± 946 | 1428 ± 340 | 340 ± 83 | 307 ± 91 | ||
| Kidney | ||||||
| M2 | 22 ± 13 | 33 ± 15 | 30 ± 11 | 101 ± 28* | ||
| M3 | 521 ± 50 | 785 ± 83* | 159 ± 34 | 208 ± 116 | ||
| Intestine | ||||||
| M2 | 374 ± 100 | 340 ± 91 | 863 ± 257 | 2706 ± 506* | ||
| M3 | N.D. | N.D. | 432 ± 108 | 905 ± 108* | ||
| Heart | ||||||
| M1 | N.D. | N.D. | 87 ± 34 | 95 ± 34 | ||
N.D., not detectable.
↵* Significantly different from controls, p < 0.05