TABLE 1

Estimation of the fractional contribution of CYP2D6 to the overall oral clearance of drug interaction victims of interest


Victim Drug

CYP2D6 EM/PM Pharmacokinetics

f2D6

Reference
Atomoxetine CLpo (l/h/kg): 0.373/0.0357 0.90 Sauer et al. (2003)
Desipramine CLpo (l/h): 102/15 0.85 Brøsen et al. (1993)
(R)-Metoprolol AUC (ng · h/ml): 408/3802 0.89 Lennard et al. (1983)
(S)-Metoprolol AUC (ng · h/ml): 679/3431 0.80 Lennard et al. (1983)
Paroxetinea AUC (nmol · h/l): 550/3910 0.86 Sindrup et al. (1992)
Perphenazine AUC (ng · h/ml): 2.18/16.8 0.87 Dahl-Puustinen et al. (1989)
Risperidone
AUC (ng · h/ml): 32/278
0.89
Huang et al. (1993)
  • a Estimated following a single dose of paroxetine