TABLE 2

Kinetic parameters of TDI of CYP3A in HLM


Inactivator

Kinetic Parameters

Reference
kinact
KI
min-1 μM
Amprenavir 0.45 0.64
0.60 0.37 Ernest et al. (2003)
Diclofenac N.D. N.D.
0.26 1600 Masubuchi et al. (2002)
Diltiazem 0.012 0.48
0.015 1 Dai et al. (2003)
Erythromycin 0.072 15.2
0.081 9.9 Dai et al. (2003)
Raloxifene 0.36 18.7
0.16 9.9 Chen et al. (2002)
Troleandomycin
0.032
2.4

  • N.D., not determined.