Phenacetin deethylase activities (pmol/mg/min) and fold-induction by omeprazole
Activities ± S.E.M. | Fold-Induction | 95% CI for Ratio | ||||
|---|---|---|---|---|---|---|
| HH1114 | Control-single | 26.4 ± 3.8 | Single | Cassette | ||
| Control-cassette | 16.1 ± 1.7 | |||||
| Omeprazole-single | 331 ± 10.6 | 12.5 ± 0.4 | 14.4 ± 0.8 | [0.8, 1.7] | ||
| Omeprazole-cassette | 232 ± 13.6 | |||||
| HH1119 | Control-single | 15.4 ± 2.1 | Single | Cassette | ||
| Control-cassette | 16.5 ± 0.5 | |||||
| Omeprazole-single | 279 ± 23.0 | 18.0 ± 1.5 | 10.9 ± 0.5 | [0.4, 0.9] | ||
| Omeprazole-cassette | 180 ± 9.0 | |||||
| HH1148 | Control-single | 4.7 ± 0.5 | Single | Cassette | ||
| Control-cassette | 5.2 ± 0.5 | |||||
| Omeprazole-single | 195 ± 7.3 | 41.4 ± 5.7 | 37.2 ± 1.4 | [0.6, 1.4] | ||
| Omeprazole-cassette | 194 ± 27.0 | |||||
| IVT | Control-single | 3.8 ± 0.0 | Single | Cassette | ||
| Control-cassette | 3.7 ± 0.1 | |||||
| Omeprazole-single | 66.7 ± 14.1 | 17.2 ± 3.7 | 14.3 ± 3.0 | [0.4, 1.6] | ||
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| Omeprazole-cassette | 52.6 ± 11.2 |
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