TABLE 2

Pharmacokinetic parameters of fexofenadine during constant infusion to EHBRs and SDRs

Data are expressed as mean ± S.E. (EHBRs and SDRs, n = 4). Statistical differences between EHBRs and SDRs were calculated by a two-sided unpaired Student's t test with p < 0.05 as the limit of significance.

	C_ss	C_liver	CL_total	CL_bile,plasma	CL_bile,liver	V_bile	Bile Flow
	nmol/l				ml/min/kg		nmol/min/kg	μl/min
SDR	680 ± 51	13.5 ± 1.4	28.3 ± 2.1	11.4 ± 1.6	0.537 ± 0.033	7.73 ± 0.78	22.6 ± 0.7
EHBR	675 ± 56	13.2 ± 0.8	27.2 ± 1.8	10.7 ± 1.9	0.496 ± 0.027	7.27 ± 0.69	14.5 ± 0.6**

↵* p < 0.05; ** p < 0.01.