The effect of removing one species from the combination of animal species on the prediction in humans based on real data
Drug | Percentage Change by Removing | ||||||
|---|---|---|---|---|---|---|---|
| Mouse | Rat | Rabbit | Dog | ||||
| Acivicin (McGovren et al., 1988) | 23.2 | 3.1 | N.A. | 17.5 | |||
| 5-Fluorouracil (Khor et al., 1997) | -43. | -9.5 | N.A. | 691.6 | |||
| Amphotericin B (Hutchaleelaha et al., 1997; Robbie and Chiou, 1998) | -38.5 | -6.2 | 17.0 | 5.2 | |||
| Amsacrine (Paxton et al., 1990) | 12.2 | -1.0 | 100.5 | -169.1 | |||
| CI-921 (Paxton et al., 1990) | -239.3 | -21.1 | 77.2 | 0.1 | |||
| AZT (Patel et al., 1990; Hussey et al., 1994) | -93.7 | -7.0 | N.A. | 91.3 | |||
| Bosentan (Ubeaud et al., 1995; Lave et al., 1996) | -169.7 | 0.1 | -251.8 | 3698.0 | |||
| Candoxatrilat (Kaye et al., 1997) | 17.2 | 0.1 | 28.7 | -89.7 | |||
| DA-1131 (Kim et al., 1998a,b) | 3.8 | 0.9 | -28.4 | 46.3 | |||
| Enprofylline (Tsunekawa et al., 1992) | 59.2 | -1.8 | 17.0 | -206.8 | |||
| Interferon (Lave et al., 1995) | 30.4 | -1.8 | -10.0 | 12.5 | |||
| Meloxicam (Busch et al., 1998) | 164.7 | 12.2 | N.A. | 50.7 | |||
| Moxifloxacin (Siefert et al., 1999) | -11.4 | 1.4 | N.A. | 64.8 | |||
| Phencyclidine (Owens et al., 1987) | 26.2 | 2.4 | N.A. | -113.5 | |||
| Propafenone (Puigdemont et al., 1991) | 0.5 | 1.6 | -2.6 | 11.4 | |||
| Sch34343 (Chung et al., 1985; Lin et al., 1987) | 65.8 | 3.8 | -26.6 | -33.5 | |||
| Sildenafil (Walker et al., 1999) | -5.2 | -1.5 | N.A. | 36.0 | |||
| Cefotetan (Komiya et al., 1981; Sawada et al., 1984; Matsushita et al., 1990) | -7.8 | 0.5 | -27.9 | -43.2 | |||
| Cefmetazole (Murakawa et al., 1980; Sawada et al., 1984) | -91.4 | 2.8 | -17.9 | -0.8 | |||
| Cefoperazone (Sawada et al., 1984) | -31.8 | 2.7 | -5.8 | -147.4 | |||
| Moxalactam (Sawada et al., 1984; Mahmood, 1999) | -22.6 | 0.9 | -7.1 | -0.7 | |||
| Cefpiramide (Sawada et al., 1984; Ohshima et al., 1991; Mahmood and Sahajwalla, 2002) | 58.7 | -0.3 | 34.7 | -422.2 | |||
| Cefazolin (Lee et al., 1980; Sawada et al., 1984) | 1.1 | -0.1 | -4.2 | -34.7 | |||
| Erythromycin (Duthu, 1985) | -8.0 | -0.7 | -21.4 | -6.2 | |||
| Oleandomycin (Duthu, 1985) | -25.3 | -7.1 | N.A. | 145.0 | |||
| rt-PA (Mordenti et al., 1991) | -7.3 | -0.3 | 14.7 | -77.8 | |||
N.A., data not available for rabbit CI-921, 9-[[2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino]-N,5-dimethyl-4-acridine carboxamide 2-hydroxyethanesulfonate (1:1); AZT, 3′-azido-3′-deoxythymidine; DA-1131, a carbapenem antibiotic; Sch34343, a penem antibiotic; rt-PA, recombinant tissue plasminogen activator.