Data (percentage of solvent control) from evaluation of reversibility of inactivation of CYP3A4 by troglitazone, rosiglitazone, and pioglitazone are reported as mean ± S.D. of eight determinations
Compound | Concentration | Without Dialysis | With Dialysis | ||||
|---|---|---|---|---|---|---|---|
| +NADPH | -NADPH | +NADPH | -NADPH | ||||
| μM | |||||||
| Troglitazone | 25 | 34.2 ± 3.2 | 90.0 ± 4.2 | 29.2 ± 1.2 | 77.0 ± 5.7 | ||
| Rosiglitazone | 25 | 59.2 ± 3.1 | 106.3 ± 4.6 | 57.5 ± 2.8 | 91.3 ± 3.6 | ||
| Pioglitazone | 25 | 78.8 ± 4.7 | 107.2 ± 6.1 | 72.5 ± 4.2 | 88.1 ± 4.4a | ||
↵ a Sample without NADPH is significantly different from that with NADPH (P < 0.01) by the Student's t test