Compound | Chemical Class | fu_{b} | CL_{int, ub, in vivo} | CL_{h} | ||||
---|---|---|---|---|---|---|---|---|
Predicted | Observed | Predicted | Observed | |||||
ml/min/kg | ml/min/kg | |||||||
Antipyrine^{a} | N | 0.94 | 0.23 | 0.60 | 0.212 | 0.55 | ||
Bosentan^{a} | A | 0.02 | 0.67 | 42.1 | 0.0134 | 3.65 | ||
Caffeine^{a} | N | 0.83 | 0.37 | 1.40 | 0.303 | 1.05 | ||
Diazepam^{a} | N | 0.012 | 3.44 | 42.78 | 0.040 | 0.5 | ||
Diltiazem^{a} | B | 0.22 | 8.45 | 205.44 | 1.70 | 13.35 | ||
Felodipine^{b} | N | 0.004 | 72.08 | 6111.11 | 0.28 | 11 | ||
Lorazepam^{a} | N | 0.094 | 1.24 | 16.71 | 0.12 | 1.45 | ||
Mibefradil^{b} | B | 0.005 | 41.3 | 4888.9 | 0.20 | 11 | ||
Midazolam^{a} | N | 0.04 | 25.74 | 599.04 | 0.98 | 10.9 | ||
Oxazepam^{a} | N | 0.03 | 1.52 | 36.94 | 0.046 | 1.05 | ||
Propranolol^{a} | B | 0.1 | 21.67 | 388.75 | 1.96 | 13.2 | ||
Theophylline^{a} | N | 0.4 | 0.35 | 1.55 | 0.141 | 0.6 | ||
Tolcapone^{a} | A | 0.0018 | 6.41 | 1650.32 | 0.074 | 2.65 | ||
Warfarin^{c} | A | 0.018 | 0.34 | 6.02 | 0.006 | 0.12 |