TABLE 2

Data for human hepatocyte incubations conducted in the presence of fetal calf serum corrected for both binding to hepatocytes (fu_inc) and fu_b

Compound	Chemical Class	fu_b	CL_{int, ub, in vivo}			CL_h
Compound	Chemical Class	fu_b				Predicted	Observed	Predicted	Observed
			ml/min/kg			ml/min/kg
Antipyrine^a	N	0.94	0.23	0.60	0.212	0.55
Bosentan^a	A	0.02	0.67	42.1	0.0134	3.65
Caffeine^a	N	0.83	0.37	1.40	0.303	1.05
Diazepam^a	N	0.012	3.44	42.78	0.040	0.5
Diltiazem^a	B	0.22	8.45	205.44	1.70	13.35
Felodipine^b	N	0.004	72.08	6111.11	0.28	11
Lorazepam^a	N	0.094	1.24	16.71	0.12	1.45
Mibefradil^b	B	0.005	41.3	4888.9	0.20	11
Midazolam^a	N	0.04	25.74	599.04	0.98	10.9
Oxazepam^a	N	0.03	1.52	36.94	0.046	1.05
Propranolol^a	B	0.1	21.67	388.75	1.96	13.2
Theophylline^a	N	0.4	0.35	1.55	0.141	0.6
Tolcapone^a	A	0.0018	6.41	1650.32	0.074	2.65
Warfarin^c	A	0.018	0.34	6.02	0.006	0.12

A, acid; B, base; N, neutral.
↵ a-c Data were obtained from ^a mean data (see Table 4); ^b Schneider et al. (1999); ^c Lave et al. (1997a,b).