TABLE 3

Data for human microsome incubations corrected for both fu_b and fu_inc

Compound	Chemical Class	Human Liver Microsomal CL_{int, in vitro}	CL_{int, ub, in vivo}
Compound	Chemical Class	Human Liver Microsomal CL_{int, in vitro}			Predicted	Observed
		μl/min/mg	ml/min/kg
Alprazolam^a	N	1.6	2.4	1.9
Amitryptyline^a	B	14	94.3	516.0
Amobarbital^a	A	0.94	1.2	1.4
Chlorpromazine^a	B	25	229.6	381.3
Clozapine^a	B	4.6	35.7	59.0
Desipramine^a	B	17	81.8	160.0
Dexamethasone^a	N	3	3.0	13.6
Diazepam^b	N	3	11.8	28.0
Diclofenac^b	A	378.02	183.8	1667.3
Diltiazem^c	B	33.5	77.7	232.6
Diphenhydramine^a	B	2.10	7.3	53.5
FK1052^d	N	58.3	182.0	1525.0
FK480^d	N	73.5	662.0	327.3
Fluvastatin^e	A	47.06	75.4	1052.0
Hexobarbital^a	A	2.3	2.9	8.3
Ibuprofen^b	A	21.79	12.3	102.4
Imipramine^a	B	19	106.6	330.0
Lorcainide^a	B	50	97.1	924.0
Methohexital^a	A	49	57.6	207.4
Methoxsalen^a	N	40	43.0	1340.0
Metoprolol^c	B	5	6.8	20.2
Midazolam^a	N	160	183.7	163.2
Nicardipine^d	N	1719	13460.0	1806.7
Nilvadipine^d	N	1695	3867.0	8123.4
Omeprazole^d	N	97.1	101.0	502.7
Phenacetin^c	N	9	9.9	212.5
Phenytoin^f	A	0.18	0.5	4.0
Prednisone^a	N	2.7	13.6	21.5
Propafenone^a	B	166	644.9	6650.0
Propranolol^c	B	13	16.3	284.5
Quinidine^a	B	3.4	10.7	22.1
Tenidap^a	A	8.3	26.2	80.4
Tenoxicam^a	A	1.7	2.2	2.2
Tolbutamide^b	A	1.94	1.3	6.4
Triazolam^a	N	19	24.6	38.1
Verapamil^b	B	122	553.6	935.3
Zolpidem^d	N	28.7	17.9	115.5

A, acid; B, base; N, neutral.

Data were obtained from ^a Obach (1999); ^b mean data (see Table 5); ^c this laboratory; ^d Naritomi et al. (2001); ^e Andersson et al. (2004); ^f Carlile et al. (1999).