Drug | CLin,u | ||
---|---|---|---|
LESA Methoda | Conventional Method (Literature Data)b | ||
μl/min/mg | μl/min/mg | ||
2-Ethoxybenzamide | 56 ± 6 | 45 ± 10 | |
Albendazole | 164 ± 33 | 200 ± 24 | |
Amiodarone | N.D.c | 15721 ± 3521 | |
Astemizole | 450 ± 308 | 10327 ± 2112 | |
Betaxolol | 78 ± 5 | 84 ± 6 | |
Bumetanide | 143 ± 19 | 147 ± 11 | |
Cerivastatin | 34 ± 5 | 21 ± 7 | |
Clozapine | 588 ± 17 | 922 ± 89 | |
Glyburide | 230 ± 10 | 178 ± 34 | |
Indapamide | 32 ± 12 | 32 ± 7 | |
Isradipine | N.D.d | 139 ± 10 | |
Metyrapone | 72 ± 9 | 38 ± 14 | |
Oxaprozin | 106 ± 2 | 96 ± 21 |
↵ a CLin,u calculated by LESA method using published CLin values obtained at 0.25, 1, and 4 mg/ml rat liver microsomes (Austin et al., 2002).
↵ b Average CLin,u calculated from published CLin and fu values at 0.25, 1, and 4 mg/ml rat liver microsomes (Austin et al., 2002).
↵ c Not determined; intercept of the 1/CLin vs. microsome concentration plot yielded a negative value.
↵ d LESA is not applicable since only two experimental CLin values were reported.