TABLE 4

Summary of drug transporters induced by xenobiotics

Human hepatocytes were treated by prototypical xenobiotics for 72 h. mRNA levels were then determined by RT-qPCR.


Transporter

Xenobiotic

Number of Responsive Cases

-Fold Inductiona
MDR1 TCDD 3/7 2.3 ± 0.5
PB 7/7 4.4 ± 1.9
RIF 7/7 2.9 ± 1.0
OPZ 6/7 2.2 ± 0.8
MRP2 PB 7/7 3.8 ± 0.8
RIF 7/7 2.5 ± 0.9
OPZ 5/7 2.4 ± 0.6
MRP3 RIF 3/7 1.7 ± 0.1
OPZ 4/7 1.8 ± 0.5
BCRP TCDD 3/7 1.6 ± 0.2
PB 6/7 3.7 ± 1.0
RIF 4/7 2.7 ± 1.2
OPZ 5/7 2.6 ± 0.4
OATP-C
RIF
5/7
2.4 ± 0.8
  • a Defined for responsive hepatocyte populations as the ratio of mRNA levels in treated hepatocytes versus xenobiotic-untreated hepatocytes and expressed as mean ± S.D. of values from three to seven responsive independent hepatocyte populations.