Summary of drug transporters repressed by xenobiotics
Human hepatocytes were treated by prototypical xenobiotics for 72 h. mRNA levels were then determined by RT-qPCR.
Transporter | Xenobiotic | Number of Responsive Cases | -Fold Repressiona |
|---|---|---|---|
| MRP6 | PB | 6/7 | 2.1 ± 0.6 |
| BSEP | TCDD | 6/7 | 2.5 ± 0.9 |
| PB | 5/7 | 9.5 ± 4 | |
| RIF | 6/7 | 5.1 ± 1.6 | |
| OPZ | 6/7 | 2.7 ± 1 | |
| OCT1 | TCDD | 3/7 | 3 ± 1.2 |
| PB | 3/7 | 3.6 ± 1.3 | |
| RIF | 5/7 | 2.6 ± 1 | |
| OATP-B | TCDD | 4/7 | 1.8 ± 0.3 |
| PB | 6/7 | 3.3 ± 2.6 | |
| OATP8 | TCDD | 7/7 | 2.3 ± 0.5 |
| PB | 3/7 | 2.4 ± 0.8 | |
| OPZ | 5/7 | 2.4 ± 1.2 | |
| OAT2 | TCDD | 4/7 | 2.2 ± 0.4 |
| PB | 7/7 | 16.6 ± 9.3 | |
| RIF | 3/7 | 2.1 ± 0.2 | |
| OPZ | 7/7 | 6.1 ± 8.4 | |
| NTCP | TCDD | 4/7 | 2.8 ± 0.7 |
| PB | 7/7 | 15.3 ± 9.3 | |
| RIF | 6/7 | 2.9 ± 1.3 | |
|
| OPZ | 4/7 | 2.7 ± 0.5 |
↵ a Defined for responsive hepatocyte populations as the ratio of mRNA levels in xenobiotic-untreated hepatocytes versus treated hepatocytes and expressed as mean ± S.D. of values from three to seven responsive independent hepatocyte populations.