TABLE 2

Percentage increase in metabolite concentration after incubation with deconjugating enzymes

Deconjugated samples were Ussing chamber medium samples incubated with mixture of compounds for 2 h (n = 4, mean ± S.E.M.).




Apical Chamber

Basolateral Chamber
1′OH-midazolam 108 ± 6.8% 110 ± 4.6%
4′OH-diclofenac 133 ± 11.6% 249 ± 30.8%
OH-bufuralol
108 ± 4.8%
92 ± 8%