TABLE 1

Binding parameter values for imipramine and propranolol in hepatocytes with or without pretreatment with ABT


Drug

Pretreatment

Binding Parameter (±S.E.)a
Bmax
Kd
BNS
Kp max
Kp min
μM μM
Imipramine None 11 ± 3.2 6.3 ± 4.6 0.77 ± 0.23 360 ± 120 150 ± 23
ABT 9.7 ± 3.6 6.2 ± 5.7 1.1 ± 0.31 380 ± 110 160 ± 29
Propranolol None 66 ± 39 36 ± 18 0.41 ± 0.11 240 ± 46 69 ± 6.8

ABT
89 ± 17
62 ± 9.9
0.30 ± 0.14
180 ± 19
63 ± 11
  • a Using eq. 3.