TABLE 2

Binding inhibition parameter values for imipramine and (S)-propranolol in the presence of various competitors


Drug

Competitor

Inhibition Parametera
sBmax
IC50
μM
Imipramine Desmethylimipramine 0.43 17
2-Hydroxyimipramine 0.43 30
Propranolol 0.41 64
(S)-Propranolol Imipramine 0.59 140

(R)-Propranolol
0.61
150
  • a Using eq. 6 and a drug concentration of 0.4 μM. Parameters were derived from mean binding data; S.E. is <10% of mean.