Drug | Competitor | Inhibition Parametera | ||
---|---|---|---|---|
sBmax | IC50 | |||
μM | ||||
Imipramine | Desmethylimipramine | 0.43 | 17 | |
2-Hydroxyimipramine | 0.43 | 30 | ||
Propranolol | 0.41 | 64 | ||
(S)-Propranolol | Imipramine | 0.59 | 140 | |
| (R)-Propranolol | 0.61 | 150 |
↵ a Using eq. 6 and a drug concentration of 0.4 μM. Parameters were derived from mean binding data; S.E. is <10% of mean.