TABLE 3

Hepatocyte propranolol clearance, based on cell, medium, or total incubate depletion compared with microsomal prediction and observed in vivo clearance

Compartment	Hepatocyte Clearance^a	CL_int
	ml/min/10⁶ cells	ml/min/g liver
Cell	0.041 ± 0.009
Medium	3.1 ± 0.8
Total incubate	1.8 ± 0.4	198
Microsomal incubate^b		193
In vivo^c		245

↵ a Mean of three incubations ± S.D.; 4 nM initial medium concentration.
↵ b D. Hallifax, unpublished data.
↵ c Ito and Houston (2004).