Summary of the in vitro permeability of the 16 compounds tested in PBMECs
Values represent the means ± S.E. of data from at least two experiments in triplicates
Compounds | Papp | Pm | Pe | log Pe |
|---|---|---|---|---|
| ×10-6 cm/s | cm/s | |||
| Sucrose | 80 ± 6 | 682 ± 10 | 92 ± 24 | -4.07 |
| Mannitol | 94 ± 6 | 765 ± 14 | 107 ± 19 | -3.99 |
| Taurocholic acid | 72 ± 5 | 521 ± 7 | 84 ± 20 | -4.09 |
| Methotrexate | 107 ± 7 | 669 ± 12 | 127 ± 40 | -3.90 |
| Vinblastine | 107 ± 6 | 530 ± 9 | 140 ± 41 | -3.88 |
| Theophylline | 185 ± 6 | 824 ± 7 | 241 ± 27 | -3.62 |
| Quinidine | 272 ± 7 | 764 ± 12 | 422 ± 85 | -3.38 |
| Metoprolol | 274 ± 8 | 640 ± 6 | 486 ± 98 | -3.32 |
| Gabapentin | 107 ± 6 | 805 ± 8 | 124 ± 33 | -3.91 |
| Phenytoin | 240 ± 7 | 841 ± 7 | 336 ± 60 | -3.47 |
| Dopamine | 590 ± 11 | 1329 ± 18 | 1066 ± 173 | -2.97 |
| Caffeine | 416 ± 4 | 600 ± 7 | 1354 ± 192 | -2.87 |
| Leucine | 224 ± 7 | 890 ± 8 | 299 ± 50 | -3.52 |
| Phenylalanine | 192 ± 8 | 849 ± 12 | 248 ± 66 | -3.61 |
| Diazepam | 746 ± 7 | 857 ± 9 | 5800 ± 3134 | -2.24 |
| Testosterone | 639 ± 8 | 786 ± 9 | 3702 ± 1458 | -2.45 |