Metabolite (M + H+ ion) | Mouse | Rat | Monkey | Human | |
---|---|---|---|---|---|
% of dose | |||||
M1 (amino acid metabolite; m/z 244) | 0.53 | 0.86 | 1.1 | N.D. | |
M2 (amino acid metabolite; m/z 244) | 0.97 | 0.72 | 4.3 | N.D. | |
M3 unknown (m/z 338) | N.D. | 0.95 | N.D. | N.D. | |
M3a unknown | 0.12 | N.D. | 1.1 | N.D. | |
M3b (2-hydroxyvarenicline; m/z 228) | N.D. | N.D. | N.D. | 2.9 | |
Varenicline (m/z 212) | 90 | 84 | 75 | 81 | |
M4 (varenicline N-carbamoylglucuronide; m/z 432) | N.D. | 1.9 | 3.6 | 3.6 |
N.D. not detected.