CYP3A4 degradation rate constant and the corresponding half-lives in humans
kdeg | Mean or Range of CYP3A4 t1/2deg | Method and Reference |
|---|---|---|
| h | ||
| 0.00008-0.0005 min-1 | 20-146 (n = 7) | Carbamazepine induction; Lai et al. (1978) |
| 0.00014 min-1 | 85 ± 61 (n = 16) | Ritonavir autoinduction; Hsu et al. (1997) |
| 0.00023-0.00032 min-1 | 36-50 (n = 8) | Rifampin induction; Fromm et al. (1996) |
| 79 | ||
| 0.00015 min-1 | (17—no decay) (n = 4) | In vitro data; Renwick et al. (2000) |