Slight changes in inactivator structure effect the inactivation and the reversibility of inactivation of P450 2E1 T303A by acetylenes
Compound | Inactivation | Reversibility | Spectral Intermediate at 483-485 nm |
|---|---|---|---|
| tBA | Mechanism-based | Yes | Yes |
| tBMP | Mechanism-based | No | No |
| 4-MP | Mechanism-based | Yes | Yes |
| tBPA | Competitive inhibition | N.A. | N.A. |
|
3-PP |
Mechanism-based |
No |
No |
N.A. refers to experiments that were not performed.