TABLE 1

Demographics, laboratory, and weight-based oral midazolam dose for 19 healthy volunteers

Data are presented as arithmetic mean ± S.D.




Total

Women

Men
Subjects (n) 19 10 9
Age (yr) 38.7 ± 8.8 38.7 ± 5.8 38.7 ± 11.6
Weight (kg) 73.4 ± 11.3 66.3 ± 8.9 81.3 ± 8.1
Body mass index (kg/m2) 25.5 ± 2.8 24.6 ± 3.2 26.4 ± 2.1
Midazolam dose (mg) 5.5 ± 0.8 5.0 ± 0.7 6.1 ± 0.6
SCr (mg/dl) 0.9 ± 0.1 0.8 ± 0.1 1.0 ± 0.1
AST (U/l) 24.9 ± 8.2 20.9 ± 5.2 29.4 ± 8.8
ALT (U/l)
29.4 ± 7.4
25.5 ± 6.8
33.8 ± 5.4
  • SCr, serum creatinine; AST, aspartate aminotransferase; ALT, alanine aminotransferase.