TABLE 1

Pharmacokinetic parameters of S4 and M1 in rats (n = 5)


Parameter

Unit

Mean ± S.D.
S4 i.v.
    VdS4 ml 112 ± 6
    kS4 min-1 0.0044 ± 0.0008
    t1/2 min 160 ± 30
    ClS4 ml/min 0.49 ± 0.07
    AUCS4 μg · min/ml 5144 ± 738
M1 iv
    VdM1 ml 115 ± 20
    ka min-1 0.0734 ± 0.0071
    kM1 min-1 0.0172 ± 0.0069
    t1/2 (M1) min 8 ± 1
    ClM1 ml/min 10.32 ± 1.82
    AUCM1 μg · min/ml 248 ± 38
    AUCS4 μg · min/ml 4099 ± 275
    fm

0.81 ± 0.05