TABLE 3

-Fold difference in brain/blood (CyA) and brain/plasma (digoxin) accumulation between mdr1a-/- and mdr1a+/+ mice of different ages

The -fold difference in CyA of mdr1a-/-/mdr1a+/+ = (brain/blood CyA mdr1a-/-/(brain/blood CyA mdr1a+/+). The -fold difference in digoxin dpm of mdr1a-/-/mdr1a+/+ = (brain/blood digoxin mdr1a-/-)/(brain/blood digoxin mdr1a+/+). Because there was no statistical difference between male and female mice, the data from these groups were combined.


Substrate

Day 1

Day 12

Day 19

6 Weeks
CyA 2.0 5.5 8.6 8.0
Digoxin
2.4
6.0
4.7
10.6