TABLE 3

Relative distribution of radioactive metabolites in pooled human bile (3-8 h) and feces (0-240 h) following single oral administration of [¹⁴C]muraglitazar

Metabolite^a	Group 1			Group 2
Metabolite^a		Feces	Urine	Bile	Feces	Urine
	% of dose				% of dose
M1	1.0	0.27		0.70	0.20
M2	1.5			1.0
M3	2.6			2.1
M4	2.0			0.70
M5	12			6.1
M6	0.90			0.4
M7	1.0			1.1
M8a	2.8			1.4
M8	3.3			0.60
M9	6.3			3.9
M10	12	0.03	0.23	4.8	0.06
M11	6.2			1.7
M12	1.0	0.02	0.52	0.50	0.05
M13	1.0	0.81	15	0.50	1.8
M14	0.40			0.30
M15	3.4		4.2	3.4
M16	12			9.5
M17a			2.5
M17b			3.8
M17c			0.72
M18a		0.15	3.7		0.15
M18b		0.46	0.84
M18c			1.9
M20		0.10	2.9		0.47
M21		0.08			0.46
Parent	23	0.23	4.0	9.6	0.47
Total	92	2.1	40	48	3.6

↵ a M2, M5, M7, M8a, M8, M11, and M14 were also detected in bile by LC/MS but in trace amounts by radioactivity.